CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1717
Family Name Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureCN5560842 family
No. of Seeds 8 No. of Other Members 32
Family Centroid CFAMM00326688 Functional Category Bioactive with Natural Product
Superfamily Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-55212-2 Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Translocator protein inhibitor SureCN13502542 family 20 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor AGN-PC-09M9MJ family 2 23
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
B2 bradykinin receptor ligand SureCN6640854 family 7 4
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Histamine H3 receptor ligand SureCN2784306 family 5 3
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
NS5B protein inhibitor AC1O5AET family 3 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... 1 2
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'... 27 20
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 7-met... 3 2
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Sonic hedgehog protein inhibitor 6-ethyl-3-(2-fluoroethoxy)-N-... 5 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Vitamin D3 receptor ligand 1-ethyl-5-[3-[4-(2-hydroxy-3,3-dime... 2 2
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 7 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Platelet-activating factor receptor ligand (7-phenylmethoxy-1H... 1 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Melanin-concentrating hormone receptor 1 ligand 6-[3-methoxy-4... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00326711 CHEMBL1209806 Bioactive CHEMBL1209806
CFAMM00326703 CHEMBL1209708 Bioactive [1-(cyclohexylmethyl)-7-methoxyindol-3-yl]-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]methanone
CFAMM00326686 CHEMBL1287876 Bioactive SureCN3519664
CFAMM00326683 CHEMBL311690 Bioactive SureCN7217490
CFAMM00326668 CHEMBL1209647 Bioactive [1-(cyclohexylmethyl)-7-methoxyindol-3-yl]-[(3R,5S)-4-ethyl-3,5-dimethylpiperazin-1-yl]methanone
CFAMM00326682 CHEMBL78663 Bioactive 7-methoxy-2-methyl-1-(2-morpholin-4-ylethyl)-N-[(2S)-3-oxo-1-phenylbutan-2-yl]indole-3-carboxamide
CFAMM00326689 CHEMBL1287847 Bioactive SureCN13225959
CFAMM00326688 CHEMBL1287846 Bioactive SureCN5560842

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26233 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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