CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17172
Family Name 5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand 1-(3-chlorophenyl)sulfonyl-6,7,8,9-tetrahydro-5H-pyrrolo[3,2-h][3]benzazepine family
No. of Seeds 6 No. of Other Members 0
Family Centroid CFAMM00440890 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 Binder Superfamily 2
Class Class 1575

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
D(1B) dopamine receptor Ligand LE-300 Family 65 452
E7820 family 9 56
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Indisu... 2 14
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1
5-hydroxytryptamine receptor 6 ligand AGN-PC-07ZA0N family 1 3
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
5-hydroxytryptamine receptor 6 ligand AGN-PC-09QKIN family 2 9
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
5-hydroxytryptamine receptor 6 ligand SureCN3147604 family 7 6
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
5-hydroxytryptamine receptor 6 ligand 1-(5-bromothiophen-2-yl)... 4 0
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-6-br... 5 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 2 0
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 7 liga... 3 11
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 3
Thromboxane A2 receptor ligand 3-[5-[(4-chlorophenyl)sulfonyla... 1 0
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03NCPD family 6 2
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00440889 CHEMBL478223 Bioactive AGN-PC-077LHJ
CFAMM00440888 CHEMBL477385 Bioactive AGN-PC-077LHK
CFAMM00440887 CHEMBL478870 Bioactive AGN-PC-077LIT
CFAMM00440891 CHEMBL518591 Bioactive AGN-PC-077LIU
CFAMM00440890 CHEMBL446054 Bioactive 1-(3-chlorophenyl)sulfonyl-6,7,8,9-tetrahydro-5H-pyrrolo[3,2-h][3]benzazepine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26816 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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