CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17214
Family Name Adenosine receptor A2a and Adenosine receptor A2b ligand SureCN4045754 family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00292158 Functional Category Bioactive
Superfamily and Adenosine receptor A2b Binder Superfamily
Class Class 3914

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
PF-3758309 family 1 8
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 14 Inhibitor 9-benzyl-6-pheny... 5 33
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
5-hydroxytryptamine receptor 6 ligand AGN-PC-031XQS family 1 1
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Cyclooxygenase 2 and Prostaglandin G/H synthase 1 inhibitor Su... 2 1
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-[4-ni... 2 1
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-(4-me... 5 4
Glycogen synthase kinase-3 beta inhibitor pyrazolopyrimidine d... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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