CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17223
Family Name Angiotensin-converting enzyme and Leukotriene A-4 hydrolase inhibitor (2S,5S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-5-[(4-propan-2-ylphenyl)methylsulfanyl]pyrrolidine-2-carboxylic acid family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00376700 Functional Category Bioactive
Superfamily Angiotensin-converting enzyme and Leukotriene A-4 hydrolase Binder Superfamily
Class Class 4521

Cousin Family NamesSeedsMembers
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Neprilysin Inhibitor Thiorphan Family 41 68
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Angiotensin-converting enzyme inhibitor Zofenoprilat family 2 14
Angiotensin-converting enzyme inhibitor (2S,4S,5R)-1-[(2R)-2-a... 1 1
Angiotensin-converting enzyme inhibitor (8S)-7-[2-[hydroxy(4-p... 1 1
Angiotensin-converting enzyme inhibitor (2S,4R)-1-[(2S)-6-amin... 6 0
Angiotensin-converting enzyme and Histone-lysine N-methyltrans... 1 19
Angiotensin-converting enzyme and Neprilysin inhibitor (5R,7S)... 1 0
Neprilysin inhibitor methyl (2S)-4-methyl-2-[[2-(sulfanylmethy... 3 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 1 5
Angiotensin-converting enzyme inhibitor N-cyclohexylcyclohexan... 2 0


External ID

Functional Category

Molecule Name

CFAMM00441164 CHEMBL499610 Bioactive (2S,5S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-5-(naphthalen-2-ylmethylsulfanyl)pyrrolidine-2-carboxylic acid
CFAMM00441163 CHEMBL499612 Bioactive (2S,5S)-5-[(3-methylphenyl)methylsulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
CFAMM00441167 CHEMBL526896 Bioactive (2S,5S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-5-(naphthalen-1-ylmethylsulfanyl)pyrrolidine-2-carboxylic acid
CFAMM00441166 CHEMBL498798 Bioactive (2S,5S)-5-benzylsulfanyl-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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