CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17234
Family Name Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhibitor AGN-PC-050UK2 family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00157480 Functional Category Bioactive
Superfamily cAMP and Glucokinase Binder Superfamily
Class Class 855

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
AP26113 family 16 90
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
PF-02545920 family 16 140
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Platelet-derived growth factor receptor beta and Ephrin type-B... 9 16
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 1 1
Vascular endothelial growth factor receptor 2 ligand F3284-701... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Mitogen-activated protein kinase 10 and Transcription factor A... 1 1
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Neuropeptide Y receptor type 5 ligand 3-[1-(2-fluorophenyl)pyr... 2 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 3 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-[2-... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Motilin receptor ligand SureCN2012437 family 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Substance-P receptor ligand (2S,3S)-N-[[2-methoxy-5-(tetrazol-... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN136... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 1
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00441251 CHEMBL504331 Bioactive AGN-PC-00S59R
CFAMM00441252 CHEMBL450918 Bioactive AGN-PC-00S52D

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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