CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17235
Family Name Insulin-like growth factor 1 receptor and Mitogen-activated protein kinase 8 ligand SureCN2205740 family
No. of Seeds 15 No. of Other Members 1
Family Centroid CFAMM00441260 Functional Category Bioactive with Natural Product
Superfamily Insulin-like growth factor 1 receptor and Tyrosine-protein kinase JAK2 Binder Superfamily
Class Class 974

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Insulin-like growth factor 1 receptor ligand 3-[[2-[2-methoxy-... 2 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 2-[4-... 1 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Insulin-like growth factor 1 receptor ligand GSK2110236A family 5 0
Insulin-like growth factor 1 receptor ligand AGN-PC-077MU8 family 2 0
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00441256 CHEMBL464344 Bioactive SureCN2206057
CFAMM00441262 CHEMBL465168 Bioactive AGN-PC-050GPB
CFAMM00441255 CHEMBL517947 Bioactive AGN-PC-050GPA
CFAMM00441261 CHEMBL457105 Bioactive AGN-PC-0682DV
CFAMM00441254 CHEMBL517163 Bioactive AGN-PC-077MUX
CFAMM00441260 CHEMBL461018 Bioactive SureCN2205740
CFAMM00441259 CHEMBL458415 Bioactive GSK2186269A
CFAMM00441258 CHEMBL450919 Bioactive AGN-PC-050GPH

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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