CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17238
Family Name Neuropeptide Y receptor type 5 ligand SureCN4464548 family
No. of Seeds 17 No. of Other Members 2
Family Centroid CFAMM00441298 Functional Category Bioactive
Superfamily Neuropeptide Y receptor type 5 and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily
Class Class 1367

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Transient receptor potential cation channel subfamily V member... 6 66
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Amg 423 family 7 47
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Reverse transcriptase Inhibitor PT-109 Family 6 7
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Prothrombin inhibitor AGN-PC-09QKE4 family 1 0
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand SureCN4477700 family 1 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Neuropeptide Y receptor type 5 and Potassium voltage-gated cha... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Beta-secretase 2 and Beta-secretase 1 inhibitor 2-cyclopropyl-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00441297 CHEMBL490561 Bioactive SureCN4464524
CFAMM00441310 CHEMBL523821 Bioactive SureCN4465951
CFAMM00441303 CHEMBL523134 Bioactive 2-[(4S)-5,5-bis(4-fluorophenyl)-4-methyl-1,4-dihydroimidazol-2-yl]pyridine-4-carbonitrile
CFAMM00441296 CHEMBL521947 Bioactive SureCN4460327
CFAMM00441309 CHEMBL523945 Bioactive SureCN4456753
CFAMM00441302 CHEMBL495034 Bioactive SureCN4472900
CFAMM00441295 CHEMBL491119 Bioactive 2-[(4S)-5,5-bis(4-fluorophenyl)-4-methyl-1,4-dihydroimidazol-2-yl]pyrazine;hydrochloride
CFAMM00441308 CHEMBL522456 Bioactive SureCN4467622
CFAMM00441307 CHEMBL491895 Bioactive SureCN4464673
CFAMM00441300 CHEMBL490903 Bioactive 4-chloro-2-[(4S,5S)-5-(4-fluorophenyl)-5-(6-fluoropyridin-3-yl)-4-methyl-1,4-dihydroimidazol-2-yl]pyridine;hydrochloride
CFAMM00441306 CHEMBL451113 Bioactive AGN-PC-0792YY
CFAMM00441305 CHEMBL521932 Bioactive SureCN4466963
CFAMM00441298 CHEMBL490123 Bioactive SureCN4464548
CFAMM00441311 CHEMBL490937 Bioactive SureCN4462939
CFAMM00441304 CHEMBL491288 Bioactive SureCN4464602

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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