CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17251
Family Name Vascular endothelial growth factor receptor 2 ligand AGN-PC-004RCV family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00441359 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor and Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 938

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Tivozanib family 4 6
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 1 4
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
Platelet-derived growth factor receptor beta and Macrophage co... 7 0
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Hepatocyte growth factor receptor and Vascular endothelial gro... 14 10
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Hepatocyte growth factor receptor ligand 1-[(E)-(2,4-difluorop... 2 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00441360 CHEMBL509707 Bioactive SureCN4381457
CFAMM00441359 CHEMBL452569 Bioactive AGN-PC-004RCV
CFAMM00441362 CHEMBL508643 Bioactive SureCN4373822
CFAMM00441361 CHEMBL452088 Bioactive SureCN4380454

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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