CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17253
Family Name Ras guanyl-releasing protein 3 and Protein kinase C alpha type inhibitor [(4E)-2-(hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate family
No. of Seeds 4 No. of Other Members 47
Family Centroid CFAMM00441405 Functional Category Bioactive with Natural Product
Superfamily Protein kinase C alpha type and Ras guanyl-releasing protein 3 Binder Superfamily
Class Class 5201

Cousin Family NamesSeedsMembers
Sodium channel protein type 10 subunit alpha Ligand Tetracaine... 6 166
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-4-ni... 1 7
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 5 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 1 1
Protein kinase C alpha type inhibitor [(4E)-2-(hydroxymethyl)-... 1 0
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 8
Putative NP ZINC35345693 Family 7 1
Putative NP ZINC00849538 Family 4 1


External ID

Functional Category

Molecule Name

CFAMM00441390 CHEMBL519398 Bioactive [(4E)-2-(hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-nitrobenzoate
CFAMM00441409 CHEMBL452307 Bioactive [(4E)-4-[[4-(dimethylamino)phenyl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate
CFAMM00441380 CHEMBL472171 Bioactive [(4E)-2-(hydroxymethyl)-4-[(3-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate
CFAMM00441405 CHEMBL488675 Bioactive [(4E)-2-(hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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