CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17258
Family Name Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-dichloroanilino)-7-methoxy-6-(2-piperidin-1-ylethylamino)quinoline-3-carboxamide family
No. of Seeds 12 No. of Other Members 7
Family Centroid CFAMM00441481 Functional Category Bioactive with Natural Product
Superfamily Macrophage colony-stimulating factor 1 receptor and Alpha-1D adrenergic receptor Binder Superfamily
Class Class 4398

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 18
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Histamine H3 receptor ligand SureCN2784306 family 5 3
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Collagenase 3 and Disintegrin and metalloproteinase domain-con... 1 2
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 5 3
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 1 0
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 0
Macrophage colony-stimulating factor 1 receptor ligand 4-[3-ch... 1 0
Acrosin and Trypsin-1 inhibitor quinolin-8-yl 4-(diaminomethyl... 1 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 1
Platelet-derived growth factor receptor beta and Vascular endo... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00441482 CHEMBL481223 Bioactive SureCN2912439
CFAMM00441475 CHEMBL480445 Bioactive SureCN2907897
CFAMM00441468 CHEMBL479445 Bioactive AGN-PC-0791BK
CFAMM00441481 CHEMBL481595 Bioactive 4-(2,3-dichloroanilino)-7-methoxy-6-(2-piperidin-1-ylethylamino)quinoline-3-carboxamide
CFAMM00441467 CHEMBL481806 Bioactive SureCN1276777
CFAMM00441466 CHEMBL452664 Bioactive 4-(2,3-dichloroanilino)-6-[2-(dimethylamino)ethylamino]-7-methoxyquinoline-3-carboxamide
CFAMM00441479 CHEMBL481008 Bioactive SureCN1276312
CFAMM00441471 CHEMBL480815 Bioactive AGN-PC-0791AP
CFAMM00441463 CHEMBL481423 Bioactive SureCN2905491
CFAMM00441477 CHEMBL480250 Bioactive SureCN2912771
CFAMM00441470 CHEMBL480814 Bioactive AGN-PC-0791AO
CFAMM00441469 CHEMBL479446 Bioactive AGN-PC-0791BM

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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