CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1726
Family Name Somatostatin receptor type 5 ligand AGN-PC-080TDB family
No. of Seeds 10 No. of Other Members 14
Family Centroid CFAMM00326814 Functional Category Bioactive with Natural Product
Superfamily Delta-type opioid receptor and Mu-type opioid receptor Ligand 6-(2-phenethylisoindolin-5-yloxy)nicotinamide Superfamily
Class Class 2449

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Smoothened homolog Inhibitor LDE225 Family 3 76
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Oxytocin receptor and Vasopressin V1a receptor Ligand L-372662... 31 23
Renin Inhibitor CP-305202 Family 9 30
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Cytochrome P4... 5 0
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Muscarinic acetylcholine receptor M2 and Acetylcholinesterase ... 4 24
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 1
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 3 68
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Cellular tumor antigen p53 and Lethal(3)malignant brain tumor-... 1 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Reverse transcriptase/RNaseH and Cytochrome P450 2C19 inhibito... 7 2
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 10 15
C-C chemokine receptor type 5 ligand 3,5-dichloro-N-[3-[4-[N-[... 2 6
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 2 1
Histamine H3 receptor ligand 6-[[2-[2-[(2R)-2-methylpyrrolidin... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 1 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Coagulation factor X inhibitor 3-Oxybenzamide 48 family 1 12
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 1
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 4 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 3
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9RLJ family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00326825 CHEMBL1210030 Bioactive SureCN2955622
CFAMM00326817 CHEMBL1210144 Bioactive SureCN2959872
CFAMM00326830 CHEMBL1210142 Bioactive SureCN2962032
CFAMM00326829 CHEMBL1210141 Bioactive SureCN2954282
CFAMM00326816 CHEMBL1210209 Bioactive AGN-PC-088VTV
CFAMM00326835 CHEMBL1210210 Bioactive AGN-PC-088VTW
CFAMM00326815 CHEMBL1210208 Bioactive AGN-PC-088VTU
CFAMM00326814 CHEMBL1210207 Bioactive AGN-PC-080TDB
CFAMM00326813 CHEMBL1210206 Bioactive AGN-PC-088VTT
CFAMM00326819 CHEMBL1210375 Bioactive AGN-PC-088VVJ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27406 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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