CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17261
Family Name Histamine H4 receptor and Histamine H1 receptor ligand 6-chloro-2-(4-methylpiperazin-1-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00291913 Functional Category Bioactive
Superfamily Beta-lactamase and Histamine H4 receptor Binder Superfamily
Class Class 343

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 3 10
Histamine H4 receptor ligand 8-bromo-4-(4-methylpiperazin-1-yl... 2 1
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Growth hormone secretagogue receptor type 1 ligand AGN-PC-00CN... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Aurora kinase A and Vascular endothelial growth factor recepto... 1 1
Lysophosphatidic acid receptor 2 ligand N-[(2S)-1-[4-(3,4-dich... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26233 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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