CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17286
Family Name Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00441641 Functional Category Bioactive
Superfamily Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
MK-6096 family 3 69
Eluxadoline family 4 85
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Thromboxane A2 receptor ligand SureCN9045130 family 4 32
Thromboxane A2 receptor ligand AC1NSKJR family 13 42
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Metabotropic glutamate receptor 5 ligand AGN-PC-09QLD2 family 1 2
Prothrombin inhibitor AGN-PC-09QMX4 family 1 4
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
Glucose-dependent insulinotropic receptor and Potassium voltag... 4 0
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 4
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Diacylglycerol O-acyltransferase 1 inhibitor 4-[5-[5-(1H-benzi... 7 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN2... 1 2
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Thromboxane A2 receptor ligand SureCN9046307 family 1 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Transient receptor potential cation channel subfamily V member... 2 0
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00441644 CHEMBL462194 Bioactive SureCN1519374
CFAMM00441643 CHEMBL454639 Bioactive AGN-PC-078WHK
CFAMM00441641 CHEMBL455446 Bioactive AGN-PC-078WHL

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27751 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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