CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17321
Family Name Oxytocin receptor and Vasopressin V1a receptor ligand 4-methoxy-N-(6-methoxypyridin-3-yl)-N-[[5-(2-methylphenyl)pyridin-2-yl]methyl]benzenesulfonamide family
No. of Seeds 9 No. of Other Members 8
Family Centroid CFAMM00352518 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Superfamily
Class Class 198

Cousin Family NamesSeedsMembers
72 kDa type IV collagenase and Interstitial collagenase Inhibi... 5 81
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Prostaglandin E2 receptor EP2 subtype Ligand CP-533536 Family 2 9
Apricoxib family 8 77
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Mitogen-activated protein kinase 12 and Mitogen-activated prot... 7 25
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-m... 2 12
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Cannabinoid receptor 2 ligand AGN-PC-09M5M9 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Aromatase inhibitor 2-(2-methoxypyridin-4-yl)-4-pyridin-3-yl-1... 1 9
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
5-hydroxytryptamine receptor 6 ligand 9-(4-methoxyphenyl)sulfo... 1 0
5-hydroxytryptamine receptor 6 ligand 1-(2-bromo-4-methoxyphen... 2 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Growth hormone secretagogue receptor type 1 ligand SureCN47965... 3 1
Orexin receptor type 2 and Orexin receptor type 1 ligand N-eth... 3 0
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 3 3
Oxytocin receptor and Vasopressin V1b receptor ligand AGN-PC-0... 1 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4... 14 12
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
DNA-(apurinic or apyrimidinic site) lyase and Alkaline phospha... 1 2
5-hydroxytryptamine receptor 6 ligand SureCN5366229 family 1 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00441821 CHEMBL456464 Bioactive 2,4-dimethoxy-N-(6-methoxypyridin-3-yl)-N-[[5-(2-methylphenyl)pyridin-2-yl]methyl]benzenesulfonamide
CFAMM00441835 CHEMBL458634 Bioactive N-[[5-(2-chlorophenyl)pyridin-2-yl]methyl]-4-methoxy-N-(6-methoxypyridin-3-yl)benzenesulfonamide
CFAMM00441834 CHEMBL514586 Bioactive N-(6-methoxypyridin-3-yl)-N-[[5-(2-methylphenyl)pyridin-2-yl]methyl]-4-methylsulfonylbenzenesulfonamide
CFAMM00441826 CHEMBL456254 Bioactive 2,5-dimethoxy-N-(6-methoxypyridin-3-yl)-N-[[5-(2-methylphenyl)pyridin-2-yl]methyl]benzenesulfonamide
CFAMM00441825 CHEMBL457544 Bioactive N-[[5-(2-fluorophenyl)pyridin-2-yl]methyl]-4-methoxy-N-(6-methoxypyridin-3-yl)benzenesulfonamide
CFAMM00441824 CHEMBL457998 Bioactive N-(6-methoxypyridin-3-yl)-N-[[5-(2-methylphenyl)pyridin-2-yl]methyl]benzenesulfonamide
CFAMM00441837 CHEMBL515818 Bioactive N-(6-methoxypyridin-3-yl)-N-[[5-(2-methylphenyl)pyridin-2-yl]methyl]pyridine-2-sulfonamide
CFAMM00441830 CHEMBL515660 Bioactive N-[[5-(2-cyanophenyl)pyridin-2-yl]methyl]-4-methoxy-N-(6-methoxypyridin-3-yl)benzenesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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