CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17328
Family Name 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine receptor 1B ligand 2-methyl-5-[2-[4-[(3-piperidin-1-ylphenyl)methyl]piperidin-1-yl]ethoxy]quinoline family
No. of Seeds 23 No. of Other Members 5
Family Centroid CFAMM00441879 Functional Category Bioactive
Superfamily Squalene synthase Inhibitor ER-119884 Superfamily
Class Class 1076

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA topoisomerase 2-beta inhibitor acridine derivative Amsacri... 1 4
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Multidrug resistance protein 3 Inhibitor LY335979 Family 1 3
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Apricoxib family 8 77
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Squalene synthase Inhibitor ER-119884 Family 2 3
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 36 18
Bloom syndrome protein and Prelamin-A/C inhibitor Dubinidine f... 1 17
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Coagulation factor X and Anionic trypsin-2 inhibitor AGN-PC-07... 1 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
D(2) dopamine receptor ligand 129722-25-4 family 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Hepatocyte growth factor receptor ligand AGN-PC-08XYVH family 1 1
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Substance-P receptor and Sodium-dependent serotonin transporte... 11 6
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 3 5
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 18 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 18 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Thyroid hormone receptor beta and Cytochrome P450 2C19 ligand ... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand N-[[(1S... 2 3
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Coagulation factor X and Prothrombin inhibitor SureCN6576845 f... 1 8
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Beta-3 adrenergic receptor ligand SureCN7133396 family 1 0
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
Gonadotropin-releasing hormone receptor ligand 3-(3,5-dimethyl... 1 3
Beta-lactamase and Muscleblind-like protein 1 inhibitor 2,3-Bi... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00441870 CHEMBL514429 Bioactive 2-methyl-5-[2-[4-[[3-(4-methyl-1,4-diazepan-1-yl)phenyl]methyl]piperidin-1-yl]ethoxy]quinoline
CFAMM00441877 CHEMBL461670 Bioactive 5-[2-[4-[[3-[(3S,5R)-3,5-dimethylpiperazin-1-yl]phenyl]methyl]piperidin-1-yl]ethoxy]-2-methylquinoline
CFAMM00441875 CHEMBL517170 Bioactive 2-methyl-5-[2-[4-[[3-[(3R)-3-methylpiperazin-1-yl]phenyl]methyl]piperidin-1-yl]ethoxy]quinoline
CFAMM00441874 CHEMBL459282 Bioactive 2-methyl-5-[2-[4-[[3-(1-methylpiperidin-4-yl)phenyl]methyl]piperidin-1-yl]ethoxy]quinoline
CFAMM00441880 CHEMBL459067 Bioactive 2-methyl-5-[2-[4-[(3-piperidin-4-ylphenyl)methyl]piperidin-1-yl]ethoxy]quinoline
CFAMM00441872 CHEMBL458199 Bioactive 2-methyl-5-[2-[4-[[3-(4-methylpiperazin-1-yl)phenyl]methyl]piperidin-1-yl]ethoxy]quinoline
CFAMM00441879 CHEMBL459061 Bioactive 2-methyl-5-[2-[4-[(3-piperidin-1-ylphenyl)methyl]piperidin-1-yl]ethoxy]quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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