CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17345
Family Name Sodium-dependent dopamine transporter and Sodium-dependent serotonin transporter inhibitor 2-(4-aminophenyl)ethyl (1R,3S,4S,5R)-3-(4-methoxyphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate;hydrochloride family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00441961 Functional Category Bioactive
Superfamily Sodium-dependent dopamine transporter and Sodium-dependent serotonin transporter Binder Superfamily 16
Class Class 2907

Cousin Family NamesSeedsMembers
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-4-ni... 1 7
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Sodium-dependent dopamine transporter and Sodium-dependent ser... 4 1
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 12
Sodium-dependent dopamine transporter inhibitor (1R,3S)-3-(4-a... 1 0
Receptor-type tyrosine-protein kinase FLT3 ligand (3Z)-5-chlor... 1 4
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 3
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Sodium-dependent dopamine transporter inhibitor 2-(4-nitrophen... 2 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 2
Retinoic acid receptor RXR-gamma and Retinoic acid receptor RX... 3 36


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00441963 CHEMBL457655 Bioactive 2-(4-acetamidophenyl)ethyl (1R,3S,4S,5R)-3-(4-methoxyphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate;hydrochloride
CFAMM00441961 CHEMBL458080 Bioactive 2-(4-aminophenyl)ethyl (1R,3S,4S,5R)-3-(4-methoxyphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate;hydrochloride
CFAMM00441965 CHEMBL457866 Bioactive 2-(4-nitrophenyl)ethyl (1R,3S,4S,5R)-3-(4-methoxyphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate;hydrochloride
CFAMM00441964 CHEMBL459332 Bioactive 2-(4-amino-3-iodophenyl)ethyl (1R,3S,4S,5R)-3-(4-methoxyphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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