CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17349
Family Name Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC-077SQ0 family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00242354 Functional Category Bioactive
Superfamily Beta-lactamase and Histamine H3 receptor Binder Superfamily
Class Class 3198

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
HIV-1 protease Inhibitor Lopinavir Family 4 25
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor Ligand A-349821 Family 49 228
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Pol polyprotein inhibitor MDL 74538 family 11 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN4877195 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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