CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17359
Family Name Prolyl endopeptidase inhibitor 2-{3-[(2s)-4,4-Difluoro-2-(Pyrrolidin-1-Ylcarbonyl)pyrrolidin-1-Yl]-3-Oxopropyl}-Isoindole-1,3(2h)-Dione family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00442033 Functional Category Bioactive
Superfamily Tumor necrosis factor Inhibitor Thalidomide Superfamily
Class Class 486

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Caspase-3 Inhibitor 2-phenethylisoquinoline-1,3,4-trione Family 6 0
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S,5S)-4-(1,3-dih... 3 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Prolyl endopeptidase inhibitor (2R)-1-[(2S)-1-[3-[(2R)-2-acety... 15 9
Prolyl endopeptidase inhibitor 2-hydroxy-1-[(2S)-1-[(2S)-1-[3-... 8 0
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Dipeptidyl peptidase 4 inhibitor SureCN2709139 family 5 7
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... 2 0
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Muscarinic acetylcholine receptor M2 ligand 3-[(1Z)-1-benzylid... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00442033 CHEMBL458975 Bioactive 2-{3-[(2s)-4,4-Difluoro-2-(Pyrrolidin-1-Ylcarbonyl)pyrrolidin-1-Yl]-3-Oxopropyl}-Isoindole-1,3(2h)-Dione
CFAMM00442035 CHEMBL515056 Bioactive 2-[3-oxo-3-[(2S)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]propyl]isoindole-1,3-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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