CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1737
Family Name P2X purinoceptor 7 inhibitor N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-2-(2,4-dimethylpyrazol-3-yl)acetamide family
No. of Seeds 3 No. of Other Members 10
Family Centroid CFAMM00326979 Functional Category Bioactive
Superfamily Neutrophil elastase and Plasma kallikrein Inhibitor (3,4-dichlorophenyl)(1h-pyrazol-1-yl)methanone Superfamily
Class Class 2424

Cousin Family NamesSeedsMembers
Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 7 19
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
P2X purinoceptor 7 inhibitor N-[(2-chloro-3,4-difluorophenyl)m... 6 64
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Lysosomal Pro-X carboxypeptidase inhibitor [(1R,2R,4S)-4-amino... 9 0
P2X purinoceptor 7 inhibitor AGN-PC-0C7PCI family 1 10


External ID

Functional Category

Molecule Name

CFAMM00326980 CHEMBL1210562 Bioactive N-[(2,4-dichlorophenyl)methyl]-2-(2,4-dimethylpyrazol-3-yl)acetamide
CFAMM00326979 CHEMBL1210563 Bioactive N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-2-(2,4-dimethylpyrazol-3-yl)acetamide
CFAMM00326977 CHEMBL1210621 Bioactive N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-2-(4-fluoro-2-methylpyrazol-3-yl)acetamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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