CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17372
Family Name Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide family
No. of Seeds 14 No. of Other Members 12
Family Centroid CFAMM00442106 Functional Category Bioactive
Superfamily Prostaglandin E2 receptor EP3 subtype Binder Superfamily 3
Class Class 1298

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Apricoxib family 8 77
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Cannabinoid receptor 2 ligand AGN-PC-09M5M9 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 3 3
Oxytocin receptor and Vasopressin V1a receptor ligand 4-methox... 9 8
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,5-dichlo... 2 9
Prostaglandin E2 receptor EP3 subtype ligand N-(benzenesulfony... 17 15
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-[4-(4-chlor... 7 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 14 2


External ID

Functional Category

Molecule Name

CFAMM00442082 CHEMBL464618 Bioactive (E)-N-(2,5-difluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamide
CFAMM00442088 CHEMBL461807 Bioactive (E)-N-(2,6-difluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamide
CFAMM00442100 CHEMBL459688 Bioactive (E)-N-(4-fluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamide
CFAMM00442106 CHEMBL460325 Bioactive (E)-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
CFAMM00442099 CHEMBL523608 Bioactive (E)-3-(1-methyl-4-quinolin-6-yloxyindol-3-yl)-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
CFAMM00442098 CHEMBL464413 Bioactive (E)-3-[4-(3,4-difluorophenoxy)-1-methylindol-3-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamide
CFAMM00442086 CHEMBL472957 Bioactive (E)-N-(3,4-difluorophenyl)sulfonyl-3-[4-(3-methoxyphenoxy)-1-methylindol-3-yl]prop-2-enamide
CFAMM00442091 CHEMBL516394 Bioactive (E)-N-(3,4-difluorophenyl)sulfonyl-3-(1-methyl-4-quinoxalin-2-yloxyindol-3-yl)prop-2-enamide
CFAMM00442097 CHEMBL521609 Bioactive (E)-N-(3,4-difluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamide
CFAMM00442096 CHEMBL489315 Bioactive (E)-3-[4-(3-methoxyphenoxy)-1-methylindol-3-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
CFAMM00442090 CHEMBL474751 Bioactive (E)-N-(3,4-difluorophenyl)sulfonyl-3-(1-methyl-4-quinolin-6-yloxyindol-3-yl)prop-2-enamide
CFAMM00442083 CHEMBL463816 Bioactive (E)-N-(2,4-difluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamide
CFAMM00442089 CHEMBL516673 Bioactive (E)-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)-N-(2,3,4,5,6-pentafluorophenyl)sulfonylprop-2-enamide
CFAMM00442101 CHEMBL522435 Bioactive (E)-3-(1-methyl-4-quinoxalin-2-yloxyindol-3-yl)-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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