CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17374
Family Name Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family
No. of Seeds 7 No. of Other Members 0
Family Centroid CFAMM00442118 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor and Tyrosine-protein kinase JAK2 Binder Superfamily
Class Class 974

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
AP26113 family 16 90
MK-6096 family 3 69
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Insulin-like growth factor 1 receptor ligand 3-[[2-[2-methoxy-... 2 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
ALK tyrosine kinase receptor and Ribosomal protein S6 kinase a... 6 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Insulin-like growth factor 1 receptor ligand GSK2110236A family 5 0
Insulin-like growth factor 1 receptor ligand AGN-PC-077MU8 family 2 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
Urotensin-2 receptor ligand 2-[(1R)-4-[(6-chloropyrazin-2-yl)a... 2 1
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00442118 CHEMBL476044 Bioactive AGN-PC-050GPS
CFAMM00442117 CHEMBL514868 Bioactive AGN-PC-050GPR
CFAMM00442116 CHEMBL464347 Bioactive AGN-PC-050GP0
CFAMM00442115 CHEMBL473669 Bioactive AGN-PC-050GPT
CFAMM00442114 CHEMBL476259 Bioactive GSK1326255A
CFAMM00442113 CHEMBL477069 Bioactive GSK1173862A

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27038 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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