CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17444
Family Name Insulin-like growth factor 1 receptor and Mitogen-activated protein kinase 8 ligand AGN-PC-050GPK family
No. of Seeds 6 No. of Other Members 0
Family Centroid CFAMM00442600 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor and Tyrosine-protein kinase JAK2 Binder Superfamily
Class Class 974

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Smoothened homolog Inhibitor LDE225 Family 3 76
MK-6096 family 3 69
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Histamine H3 receptor ligand SureCN7251693 family 3 1
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940907 family 2 21
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940986 family 1 0
Insulin-like growth factor 1 receptor ligand 3-[[2-[2-methoxy-... 2 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Insulin-like growth factor 1 receptor ligand GSK2110236A family 5 0
Insulin-like growth factor 1 receptor ligand AGN-PC-077MU8 family 2 0
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00442598 CHEMBL516816 Bioactive AGN-PC-050GOU
CFAMM00442597 CHEMBL511765 Bioactive GSK2213727A
CFAMM00442596 CHEMBL465789 Bioactive AGN-PC-050GPM
CFAMM00442601 CHEMBL468619 Bioactive SureCN2203953
CFAMM00442600 CHEMBL516870 Bioactive AGN-PC-050GPK
CFAMM00442599 CHEMBL467136 Bioactive AGN-PC-050GPL

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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