CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17445
Family Name Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 inhibitor SureCN5593956 family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00442605 Functional Category Bioactive
Superfamily Prostaglandin G/H synthase 1 and Coagulation factor X Binder Superfamily
Class Class 2000

Cousin Family NamesSeedsMembers
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 6 60
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Cannabinoid receptor 2 ligand 2-tert-butyl-5-ethylsulfonyl-1-(... 28 32
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-009WYJ f... 1 4
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 10
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
Cannabinoid receptor 2 ligand 4-[2-tert-butyl-1-(oxan-4-ylmeth... 5 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 1
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 2 1
Prostaglandin G/H synthase 2 inhibitor AGN-PC-00GDEY family 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00442602 CHEMBL46623 Bioactive SureCN5593984
CFAMM00442605 CHEMBL46584 Bioactive SureCN5593956

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26230 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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