CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17452
Family Name Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-PC-071TC0 family
No. of Seeds 7 No. of Other Members 2
Family Centroid CFAMM00232456 Functional Category Bioactive
Superfamily Mast/stem cell growth factor receptor Kit and Vascular endothelial growth factor receptor 2 Ligand Motesanib Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Translocator protein Inhibitor Emapunil Family 7 89
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Amg 423 family 7 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Transient receptor potential cation channel subfamily V member... 2 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 4
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 3 6
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Gonadotropin-releasing hormone receptor ligand AGN-PC-074DKH f... 15 46
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Transient receptor potential cation channel subfamily V member... 2 1
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-pyr... 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
Transient receptor potential cation channel subfamily V member... 57 4
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4... 2 2
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Adenosine receptor A1 and Adenosine receptor A3 ligand CHEMBL4... 2 0
Transient receptor potential cation channel subfamily V member... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Cannabinoid receptor 2 ligand AGN-PC-07CRHA family 4 8
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 inhibitor 3-(2,4-dioxo-7,8-dihy... 5 1
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0
Calcitonin gene-related peptide type 1 receptor ligand N-[5-(4... 3 1
Calcitonin gene-related peptide type 1 receptor ligand N-(1-me... 1 3
Calcitonin gene-related peptide type 1 receptor ligand N-[1-me... 1 1
Stromelysin-1 and Interstitial collagenase inhibitor 1-[(2S)-1... 1 3
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(prop... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00442664 CHEMBL467476 Bioactive AGN-PC-071TBZ
CFAMM00442661 CHEMBL467896 Bioactive ZINC05304944

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26194 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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