CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17463
Family Name Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureCN3482331 family
No. of Seeds 7 No. of Other Members 0
Family Centroid CFAMM00442737 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 and Sodium channel protein type 1 subunit alpha Binder Superfamily
Class Class 2568

Cousin Family NamesSeedsMembers
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
C-reactive protein Inhibitor ISIS-CRP Family 4 105
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Sodium channel protein type 1 subunit alpha and Sodium channel... 1 2
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Prostaglandin D2 receptor ligand N-[2-(2,4-dichlorophenyl)ethy... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Cannabinoid receptor 1 ligand SureCN675796 family 5 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... 5 17
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 5 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Dihydrofolate reductase inhibitor 5-[4-[(3,4-dichlorophenyl)me... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 6-(2-... 1 2
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 17 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Fibroblast growth factor receptor 1 and Proto-oncogene tyrosin... 2 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-07... 1 1
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor 5-ami... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 6-(2-... 2 0
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 3 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 4-N-[... 16 21


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00442737 CHEMBL466686 Bioactive SureCN3482331
CFAMM00442736 CHEMBL466294 Bioactive SureCN3481560
CFAMM00442742 CHEMBL511774 Bioactive SureCN3482083
CFAMM00442741 CHEMBL513648 Bioactive SureCN3482097
CFAMM00442740 CHEMBL513812 Bioactive SureCN3482118
CFAMM00442739 CHEMBL512422 Bioactive SureCN3482421
CFAMM00442738 CHEMBL466685 Bioactive SureCN3482735

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26839 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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