CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17474
Family Name Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)-8-[bis(2-chlorophenyl)methyl]-3-(5-fluoropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide family
No. of Seeds 4 No. of Other Members 17
Family Centroid CFAMM00442779 Functional Category Bioactive
Superfamily Glycogen phosphorylase, muscle form Inhibitor PSN357 Superfamily
Class Class 913

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Triprolidine Family 19 316
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Transient receptor potential cation channel subfamily V member... 16 295
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(4) dopamine receptor Ligand SPI-376 Family 7 84
ABC294640 family 5 75
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
B1 bradykinin receptor ligand ELN-441958 family 1 0
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloro-4-fl... 6 7
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Substance-P receptor ligand SureCN7796965 family 9 1
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 2 0
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
Glucocorticoid receptor ligand 5-[(6-methylpyridin-2-yl)methyl... 3 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00442786 CHEMBL513831 Bioactive (1R,5R)-8-[bis(2-chlorophenyl)methyl]-3-(4,5-difluoropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
CFAMM00442779 CHEMBL466683 Bioactive (1R,5R)-8-[bis(2-chlorophenyl)methyl]-3-(5-fluoropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
CFAMM00442778 CHEMBL467514 Bioactive (1R,5R)-8-[bis(2-chlorophenyl)methyl]-3-(6-fluoropyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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