CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17527
Family Name RAC-alpha serine/threonine-protein kinase and RAC-gamma serine/threonine-protein kinase inhibitor AGN-PC-04RN0E family
No. of Seeds 20 No. of Other Members 7
Family Centroid CFAMM00443123 Functional Category Bioactive
Superfamily RAC-alpha serine/threonine-protein kinase and RAC-gamma serine/threonine-protein kinase Binder Superfamily
Class Class 3284

Cousin Family NamesSeedsMembers
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 37 57
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 1 0
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Prelamin-A/C and Lethal(3)malignant brain tumor-like protein 1... 1 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 11
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Melanocortin receptor 4 ligand AGN-PC-076ANF family 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 6-ami... 3 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Coagulation factor X inhibitor SureCN8290907 family 2 2
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 0
RAC-gamma serine/threonine-protein kinase and RAC-alpha serine... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 1
Probable G-protein coupled receptor 142 ligand (2S)-3-phenyl-N... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00443122 CHEMBL520788 Bioactive SureCN4582818
CFAMM00443135 CHEMBL512858 Bioactive AGN-PC-04RN0C
CFAMM00443128 CHEMBL469802 Bioactive AGN-PC-04RMMN
CFAMM00443121 CHEMBL470597 Bioactive N-[(2S)-1-amino-3-phenylpropan-2-yl]-4-bromo-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
CFAMM00443127 CHEMBL470410 Bioactive AGN-PC-04ROGE
CFAMM00443120 CHEMBL523586 Bioactive SureCN4583680
CFAMM00443133 CHEMBL498051 Bioactive SureCN4583338
CFAMM00443119 CHEMBL470598 Bioactive SureCN4583557
CFAMM00443132 CHEMBL498052 Bioactive N-[(2S)-1-amino-3-(2-fluorophenyl)propan-2-yl]-4-bromo-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
CFAMM00443125 CHEMBL471034 Bioactive AGN-PC-04ROGC
CFAMM00443138 CHEMBL512480 Bioactive AGN-PC-04ROBV
CFAMM00443118 CHEMBL482536 Bioactive SureCN4603822
CFAMM00443137 CHEMBL496690 Bioactive N-[(2S)-1-amino-3-(4-fluorophenyl)propan-2-yl]-4-bromo-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
CFAMM00443124 CHEMBL469781 Bioactive AGN-PC-04RNHP
CFAMM00443117 CHEMBL470596 Bioactive AGN-PC-04RNR1
CFAMM00443123 CHEMBL469590 Bioactive AGN-PC-04RN0E
CFAMM00443136 CHEMBL469591 Bioactive AGN-PC-04RNMJ
CFAMM00443129 CHEMBL471059 Bioactive AGN-PC-04RNR2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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