CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17528
Family Name Translocator protein inhibitor AGN-PC-04X3HY family
No. of Seeds 10 No. of Other Members 1
Family Centroid CFAMM00443151 Functional Category Bioactive
Superfamily Cholecystokinin receptor type A and Prelamin-A/C Binder Superfamily
Class Class 227

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 7 0
Translocator protein inhibitor AGN-PC-080ILF family 9 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Substance-P receptor ligand SureCN7659714 family 2 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand pheny... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Peroxisome proliferator-activated receptor gamma ligand (2S)-2... 8 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Cholecystokinin receptor type A ligand SureCN3132309 family 11 0
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
Metabotropic glutamate receptor 5 ligand AGN-PC-0760YR family 1 0
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-meth... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00443149 CHEMBL484573 Bioactive AGN-PC-04X2CK
CFAMM00443143 CHEMBL484932 Bioactive AGN-PC-04X3HZ
CFAMM00443141 CHEMBL485606 Bioactive AGN-PC-04UEKV
CFAMM00443148 CHEMBL484574 Bioactive AGN-PC-04X3HX
CFAMM00443140 CHEMBL484741 Bioactive AGN-PC-04X2GO
CFAMM00443147 CHEMBL469681 Bioactive AGN-PC-04TFZO
CFAMM00443146 CHEMBL469680 Bioactive AGN-PC-04TFZM
CFAMM00443145 CHEMBL521186 Bioactive AGN-PC-04UEKU
CFAMM00443151 CHEMBL509917 Bioactive AGN-PC-04X3HY
CFAMM00443144 CHEMBL483172 Bioactive AGN-PC-04X2GP

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27285 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543