CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17566
Family Name Tyrosine-protein kinase SYK and Lysine--tRNA ligase inhibitor 5-[[(1S,2R)-2-aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamide family
No. of Seeds 8 No. of Other Members 8
Family Centroid CFAMM00427678 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Bifunctional dihydrofolate reductase-thymidylate synthase Binder Superfamily 4
Class Class 1144

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Fibroblast growth factor receptor 1 and Vascular endothelial g... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 5 12
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1


External ID

Functional Category

Molecule Name

CFAMM00443336 CHEMBL474654 Bioactive 5-[[(1R,2S)-2-aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide
CFAMM00443345 CHEMBL474832 Bioactive 5-[[(2R)-2-aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-2-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide
CFAMM00443335 CHEMBL516061 Bioactive 5-[[(2R)-2-aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamide
CFAMM00443344 CHEMBL471948 Bioactive 5-[[(2R)-2-aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide
CFAMM00443342 CHEMBL474582 Bioactive 5-(2-aminoethylamino)-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamide
CFAMM00443337 CHEMBL514012 Bioactive 5-[[(1R,2S)-2-aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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