CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17582
Family Name 5-hydroxytryptamine receptor 2B ligand SureCN1299002 family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00443460 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Lysosomal alpha-glucosidase Binder Superfamily
Class Class 2020

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Eluxadoline family 4 85
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Thromboxane A2 receptor ligand AC1NSKJR family 13 42
Mitogen-activated protein kinase 14 inhibitor DEL-B, 14b family 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Transient receptor potential M8 protein ligand (3E)-3-[5-[2-(t... 4 2
Pol polyprotein and Renin inhibitor U-75875 family 12 1
Pol polyprotein inhibitor N-[(3R,4R,5R)-5-[[(2S)-1-(1H-benzimi... 5 4
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 1 6
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
Histamine H1 receptor and Substance-P receptor ligand SureCN13... 24 48
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Histamine H1 receptor and Substance-P receptor ligand AGN-PC-0... 10 6
Substance-P receptor and Histamine H1 receptor ligand SureCN13... 2 0
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Pol polyprotein inhibitor AC1LAQDX family 3 0
C-C chemokine receptor type 5 ligand SureCN13543570 family 2 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00443456 CHEMBL475778 Bioactive SureCN1298886
CFAMM00443460 CHEMBL472789 Bioactive SureCN1299002

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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