CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17583
Family Name Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]phenyl]-2-fluoro-5-methylbenzamide family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00443465 Functional Category Bioactive
Superfamily Mast/stem cell growth factor receptor Kit and Vascular endothelial growth factor receptor 2 Ligand Motesanib Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Substance-P receptor ligand Netupitant family 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 5 5
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00443466 CHEMBL474489 Bioactive 3-chloro-N-[3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]phenyl]-4-fluorobenzamide
CFAMM00443465 CHEMBL474695 Bioactive N-[3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]phenyl]-2-fluoro-5-methylbenzamide
CFAMM00443468 CHEMBL473061 Bioactive N-[3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]phenyl]-3-(trifluoromethyl)benzamide
CFAMM00443467 CHEMBL472864 Bioactive N-[3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]phenyl]-4-methylbenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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