CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17600
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1-trifluoro-2-[4-[(2R)-2-methyl-4-(2-pyridin-4-ylethyl)piperazin-1-yl]sulfonylphenyl]propan-2-ol family
No. of Seeds 12 No. of Other Members 3
Family Centroid CFAMM00443551 Functional Category Bioactive
Superfamily Corticosteroid 11-beta-dehydrogenase isozyme 1 and Cannabinoid receptor 2 Binder Superfamily
Class Class 3565

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Histamine H1 receptor Ligand Doxylamine Family 2 91
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
Platelet-activating factor receptor ligand SureCN9852997 family 1 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [1-[4... 2 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1


External ID

Functional Category

Molecule Name

CFAMM00443542 CHEMBL490966 Bioactive SureCN5111053
CFAMM00443541 CHEMBL522463 Bioactive SureCN5111797
CFAMM00443548 CHEMBL491489 Bioactive SureCN3948470
CFAMM00443540 CHEMBL489708 Bioactive 1,1,1-trifluoro-2-[4-[(2R)-2-methyl-4-(2-pyridin-2-ylethyl)piperazin-1-yl]sulfonylphenyl]propan-2-ol
CFAMM00443539 CHEMBL490967 Bioactive SureCN5112811
CFAMM00443546 CHEMBL491141 Bioactive 1,1,1-trifluoro-2-[4-[(2R)-2-methyl-4-[(1-pyridin-4-ylcyclobutyl)methyl]piperazin-1-yl]sulfonylphenyl]propan-2-ol
CFAMM00443545 CHEMBL523444 Bioactive 1,1,1-trifluoro-2-[4-[(2R)-2-methyl-4-(2-pyridin-3-ylethyl)piperazin-1-yl]sulfonylphenyl]propan-2-ol
CFAMM00443551 CHEMBL473554 Bioactive 1,1,1-trifluoro-2-[4-[(2R)-2-methyl-4-(2-pyridin-4-ylethyl)piperazin-1-yl]sulfonylphenyl]propan-2-ol
CFAMM00443537 CHEMBL473757 Bioactive 2-[4-[(2R)-2-methyl-4-(2-pyridin-4-ylethyl)piperazin-1-yl]sulfonylphenyl]propan-2-ol
CFAMM00443544 CHEMBL491146 Bioactive 1,1,1-trifluoro-2-[4-[(2R)-2-methyl-4-[(1-pyridin-3-ylcyclopentyl)methyl]piperazin-1-yl]sulfonylphenyl]propan-2-ol
CFAMM00443550 CHEMBL490953 Bioactive SureCN4051367

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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