CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17639
Family Name Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family
No. of Seeds 12 No. of Other Members 6
Family Centroid CFAMM00443684 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Prothrombin Inhibitor Dabigatran Family 7 182
CC-486 family 7 103
JAK Inhibitor Momelotinib Family 33 83
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Muscarinic acetylcholine receptor M1 Ligand Bo(15)pz Family 4 5
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 11 and Mitogen-activated prot... 10 31
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Estrogen receptor beta and Peroxisome proliferator-activated r... 1 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Prelamin-A/C and Niemann-Pick C1 protein inhibitor CHEMBL13592... 1 16
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 9 1
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
cAMP-dependent protein kinase catalytic subunit beta and cAMP-... 2 9
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Melanocortin receptor 4 ligand AGN-PC-076ANF family 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand N-... 1 12
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Histone deacetylase 1 and Potassium voltage-gated channel subf... 3 2
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand N-... 2 17
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 7 11
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-04XL74 family 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Mitogen-activated protein kinase 14 inhibitor N-[4-methyl-3-[6... 1 1
Tyrosine-protein kinase ITK/TSK inhibitor SureCN6632543 family 1 2
Histone deacetylase 1 inhibitor SureCN1066177 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00443671 CHEMBL521113 Bioactive AGN-PC-04XL7D
CFAMM00443684 CHEMBL519960 Bioactive AGN-PC-00A4QJ
CFAMM00443670 CHEMBL488596 Bioactive N-[1-(3-amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-5-[(E)-2-pyrazin-2-ylethenyl]thiophene-2-carboxamide
CFAMM00443683 CHEMBL520110 Bioactive AGN-PC-04XL7C
CFAMM00443676 CHEMBL485922 Bioactive N-[1-(3-amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-5-[(E)-2-pyridin-3-ylethenyl]thiophene-2-carboxamide
CFAMM00443675 CHEMBL481378 Bioactive AGN-PC-04XL6Y
CFAMM00443674 CHEMBL501661 Bioactive N-[1-(3-amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-5-[(E)-2-(6-aminopyridin-2-yl)ethenyl]thiophene-2-carboxamide
CFAMM00443680 CHEMBL481738 Bioactive AGN-PC-04XL7B
CFAMM00443673 CHEMBL475593 Bioactive AGN-PC-04XL7E
CFAMM00443679 CHEMBL481900 Bioactive AGN-PC-04XL7F
CFAMM00443672 CHEMBL486951 Bioactive N-[1-(3-amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-5-[(E)-2-pyridin-2-ylethenyl]thiophene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27759 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543