CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17651
Family Name Histamine H3 receptor and Potassium voltage-gated channel subfamily H member 2 ligand AGN-PC-00E1DT family
No. of Seeds 28 No. of Other Members 30
Family Centroid CFAMM00443775 Functional Category Bioactive with Natural Product
Superfamily Histamine H3 receptor and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily 4
Class Class 3845

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Extracellular calcium-sensing receptor Ligand 2-furan-2-yl-3-p... 4 119
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxy-phenyl)-... 1 3
Poly [ADP-ribose] polymerase 1 Inhibitor 8-methoxy-2-phenyl-3h... 4 6
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 28 91
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
Vasopressin V1b receptor ligand AGN-PC-00HJ2S family 4 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor SureC... 2 3
C-X-C chemokine receptor type 3 ligand N-(2-ethoxyethyl)-N-[(1... 1 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Ghrelin/growth hormone secretagogue receptor and Cytochrome P4... 5 20
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 18
Coagulation factor X and Trypsin-1 inhibitor SureCN7484452 family 3 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 16 2
Histamine H3 receptor ligand AGN-PC-03Z8FM family 5 0
Histamine H3 receptor ligand AGN-PC-00AE5Q family 13 13
Histamine H3 receptor ligand AGN-PC-03Z8HJ family 4 1
5-hydroxytryptamine receptor 7 ligand 4-[4-(2-ethoxyphenyl)pip... 2 5
Adenosine receptor A2a and Amine oxidase [flavin-containing] B... 4 0
Beta-lactamase and 4'-phosphopantetheinyl transferase ffp inhi... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00443720 CHEMBL478406 Bioactive AGN-PC-00DC4U
CFAMM00443775 CHEMBL476373 Bioactive AGN-PC-00E1DT
CFAMM00443726 CHEMBL479241 Bioactive AGN-PC-04UGWD
CFAMM00443755 CHEMBL484740 Bioactive AGN-PC-03Z8FH
CFAMM00443732 CHEMBL478621 Bioactive AGN-PC-00EGYL
CFAMM00443761 CHEMBL477361 Bioactive SureCN3944761
CFAMM00443725 CHEMBL479242 Bioactive AGN-PC-00DREL
CFAMM00443760 CHEMBL477360 Bioactive SureCN4465836
CFAMM00443773 CHEMBL478615 Bioactive AGN-PC-04UIK1
CFAMM00443724 CHEMBL515150 Bioactive AGN-PC-03Z8HQ
CFAMM00443753 CHEMBL519018 Bioactive AGN-PC-03Z8DU
CFAMM00443745 CHEMBL477356 Bioactive AGN-PC-00DWM7
CFAMM00443759 CHEMBL477364 Bioactive AGN-PC-04UIO3
CFAMM00443772 CHEMBL478616 Bioactive AGN-PC-04UIK2
CFAMM00443765 CHEMBL515004 Bioactive AGN-PC-04UIO5
CFAMM00443758 CHEMBL521022 Bioactive AGN-PC-03Z8HO
CFAMM00443729 CHEMBL485242 Bioactive AGN-PC-04X2ZN
CFAMM00443771 CHEMBL477991 Bioactive AGN-PC-03Z8FI
CFAMM00443728 CHEMBL476106 Bioactive AGN-PC-04UGWF
CFAMM00443777 CHEMBL515477 Bioactive SureCN4483425
CFAMM00443770 CHEMBL479252 Bioactive AGN-PC-04UIO2
CFAMM00443721 CHEMBL479036 Bioactive AGN-PC-04UGWC
CFAMM00443750 CHEMBL477152 Bioactive AGN-PC-04UIBQ
CFAMM00443776 CHEMBL476579 Bioactive SureCN4476222
CFAMM00443769 CHEMBL476723 Bioactive AGN-PC-00AOYU

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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