CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17664
Family Name Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluorophenyl)-4-(1H-imidazol-5-yl)butan-2-one;dihydrochloride family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00443829 Functional Category Bioactive
Superfamily Histamine H3 receptor and Histidinol dehydrogenase Binder Superfamily
Class Class 2757

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Renin Inhibitor Remikiren Family 100 126
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
Histamine H3 receptor Ligand Proxyfan Family 12 32
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 2
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 6 6
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Histamine H3 receptor Ligand GT-2016 Family 4 6
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Lysosomal Pro-X carboxypeptidase inhibitor N-[(2S)-1-[(2S)-2-(... 1 0
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(3,4-dichlor... 2 1
Histamine H4 receptor and Histamine H3 receptor ligand AGN-PC-... 1 2
Glucocorticoid receptor ligand SureCN13513652 family 1 0
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00443829 CHEMBL477470 Bioactive (3S)-3-amino-1-(2,4-difluorophenyl)-4-(1H-imidazol-5-yl)butan-2-one;dihydrochloride
CFAMM00443828 CHEMBL556975 Bioactive (3S)-3-amino-1-(2,4-difluorophenyl)-4-(1H-imidazol-5-yl)butan-2-one;hydrochloride
CFAMM00443831 CHEMBL476671 Bioactive (3S)-3-amino-4-(1H-imidazol-5-yl)-1-(2,3,4,5,6-pentafluorophenyl)butan-2-one;dihydrochloride
CFAMM00443830 CHEMBL534949 Bioactive (3S)-3-amino-1-(4-bromophenyl)-4-(1H-imidazol-5-yl)butan-2-one;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26851 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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