CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17666
Family Name Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-difluorophenoxy)methyl]-3-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-methylbenzimidazole family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00443837 Functional Category Bioactive
Superfamily Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-imidazol-1-yl-phenoxy)-propyl]-pyridine Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Neuropeptide Y receptor type 1 ligand 2-[(4-chlorophenoxy)meth... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 15
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Mu-type opioid receptor and Nitric oxide synthase, brain ligan... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
5-hydroxytryptamine receptor 1A ligand AGN-PC-04UH85 family 2 3
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cannabinoid receptor 2 ligand SureCN14457828 family 1 0
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-07ZH03... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00443840 CHEMBL477375 Bioactive 2-[[(1R,5S)-6-[(4-chloro-2-fluorophenoxy)methyl]-3-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-methylbenzimidazole
CFAMM00443837 CHEMBL476998 Bioactive 2-[[(1R,5S)-6-[(2,5-difluorophenoxy)methyl]-3-azabicyclo[3.1.0]hexan-3-yl]methyl]-1-methylbenzimidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26413 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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