CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17682
Family Name Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ligand N-[2-[4-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1,4-diazepan-1-yl]ethyl]-2-phenoxypyridine-3-carboxamide family
No. of Seeds 6 No. of Other Members 1
Family Centroid CFAMM00443900 Functional Category Bioactive
Superfamily Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor Binder Superfamily 8
Class Class 2449

Cousin Family NamesSeedsMembers
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Survival motor neuron protein and Lysine-specific demethylase ... 1 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 10 15
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 2 1
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 10 13
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Reverse transcriptase/RNaseH inhibitor 7CN-6Et-9Me-PBOA-5one f... 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00443909 CHEMBL488974 Bioactive N-[2-[4-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-1,4-diazepan-1-yl]ethyl]-2-phenoxypyridine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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