CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1769
Family Name Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6-morpholin-4-ylpyridin-3-yl)ethynyl]pyrimidin-4-amine family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00327225 Functional Category Bioactive
Superfamily Adenosine kinase and Epidermal growth factor receptor Binder Superfamily
Class Class 920

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 15 457
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor PF-0048... 2 13
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Adenosine kinase inhibitor AGN-PC-074UAJ family 3 10
Adenosine kinase inhibitor abt-702 family 14 1
Corticotropin-releasing factor receptor 1 ligand 3-(2-bromo-4-... 13 34
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Deoxycytidine kinase inhibitor AGN-PC-07Z9B3 family 2 7
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Epidermal growth factor receptor ligand AGN-PC-076GVG family 8 1
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Epidermal growth factor receptor ligand AGN-PC-076GXM family 6 0
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 11 2
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Transient receptor potential cation channel subfamily V member... 2 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 1 0
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Epidermal growth factor receptor ligand 4-Anilinopyrido[3,4-d]... 2 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Epidermal growth factor receptor ligand AGN-PC-078X9P family 4 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Adenosine kinase inhibitor AGN-PC-074DKZ family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00327225 CHEMBL445566 Bioactive 5-[3-(3-bromophenyl)propyl]-6-[2-(6-morpholin-4-ylpyridin-3-yl)ethynyl]pyrimidin-4-amine
CFAMM00327224 CHEMBL122652 Bioactive AGN-PC-00EZV4
CFAMM00327223 CHEMBL121391 Bioactive 5-N-[(3-bromophenyl)methyl]-5-N-methyl-6-[2-(6-morpholin-4-ylpyridin-3-yl)ethynyl]pyrimidine-4,5-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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