CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17701
Family Name Leukotriene A-4 hydrolase inhibitor SureCN5313952 family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00444011 Functional Category Bioactive
Superfamily Leukotriene A-4 hydrolase and Matrix metalloproteinase-9 Binder Superfamily
Class Class 3140

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Histamine H1 receptor Ligand Tranilast Family 5 125
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(4... 2 6
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 5
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
Leukotriene A-4 hydrolase inhibitor AGN-PC-0A9QDC family 2 5
Transient receptor potential cation channel subfamily V member... 1 2
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 3 11
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Capsid scaffolding protein inhibitor AC1MHP1L family 3 6
Leukotriene A-4 hydrolase inhibitor 4-[[(1S,5R)-3-[4-(2-fluoro... 2 2
Capsid scaffolding protein inhibitor AC1MHP20 family 3 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 1
3,5-bis[[2-(4-methoxyphenoxy)acetyl]amino]benzoate NP Agn-pc-0... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444010 CHEMBL479561 Bioactive SureCN5314908
CFAMM00444009 CHEMBL480125 Bioactive SureCN5314376
CFAMM00444012 CHEMBL480719 Bioactive SureCN5310536
CFAMM00444011 CHEMBL479552 Bioactive SureCN5313952

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44475 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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