CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17705
Family Name Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[(2R)-2-benzyl-3-oxo-2,4-dihydroquinoxalin-1-yl]methyl]-N-hydroxybenzamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00146303 Functional Category Bioactive
Superfamily Histone deacetylase 2 and Histone deacetylase 1 Binder Superfamily 9
Class Class 1299

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Vasopressin V2 receptor Ligand VP-343 Family 1 0
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor L-750034 Family 7 38
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Transient receptor potential cation channel subfamily V member... 1 5
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Cholecystokinin receptor type A Ligand VL-0494 Family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
Histone deacetylase 1 inhibitor 2-[4-[(2-aminophenyl)carbamoyl... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24520 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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