CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17709
Family Name Nociceptin receptor and Delta-type opioid receptor ligand 2-[3-[1-[1-(1-methylcyclooctyl)piperidin-4-yl]benzimidazol-2-yl]phenoxy]ethanol family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00295449 Functional Category Bioactive
Superfamily Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-imidazol-1-yl-phenoxy)-propyl]-pyridine Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Neuropeptide Y receptor type 1 ligand 2-[(4-chlorophenoxy)meth... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 15
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 4 4
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
D(2) dopamine receptor ligand SureCN11039666 family 1 4
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
5-hydroxytryptamine receptor 1A ligand AGN-PC-04UH85 family 2 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 1 1
Dihydrofolate reductase inhibitor 5-[3-(3-methoxy-5-morpholin-... 2 0
Thromboxane A2 receptor ligand SureCN9681521 family 1 0
DNA-(apurinic or apyrimidinic site) lyase and Survival motor n... 1 2
Beta-lactamase and Microtubule-associated protein tau inhibito... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26843 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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