| Cousin Family Names | Seeds | Members |
|---|
| 5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family | 7 | 460 |
| Omega 1 Benzodiazepine receptor Ligand Zaleplon Family | 6 | 589 |
| Type-1 angiotensin II receptor Ligand Forasartan Family | 3 | 253 |
| Metabotropic glutamate receptor 5 Ligand ADX-48621 Family | 15 | 444 |
| C-X-C chemokine receptor type 4 Ligand AMD-070 Family | 12 | 800 |
| Cyclin-dependent kinase 2 Inhibitor Seliciclib Family | 29 | 292 |
| Interleukin-12 subunit alpha Inhibitor STA-5326 Family | 2 | 51 |
| HER Inhibitor AC480 Family | 4 | 67 |
| Fibroblast growth factor receptor 2 and Fibroblast growth fact... | 11 | 86 |
| Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family | 3 | 130 |
| C-reactive protein Inhibitor ISIS-CRP Family | 4 | 105 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 14 | 234 |
| Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family | 53 | 580 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 35 | 270 |
| Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... | 13 | 55 |
| GDC-0349 family | 44 | 77 |
| SCH-900776 family | 8 | 14 |
| PF-4217903 family | 14 | 65 |
| Tryptase Inhibitor Babim Family | 12 | 90 |
| D(4) dopamine receptor Ligand L-745,870 Family | 30 | 205 |
| Corticotropin-releasing factor receptor 1 Ligand R121919 Family | 26 | 84 |
| Interleukin-1 receptor type 1 and Mitogen-activated protein ki... | 7 | 151 |
| Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... | 10 | 43 |
| Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... | 31 | 66 |
| TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... | 3 | 63 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... | 13 | 14 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... | 18 | 109 |
| Vascular endothelial growth factor receptor 1 and Vascular end... | 6 | 23 |
| Epidermal growth factor receptor Ligand PD-158780 Family | 98 | 89 |
| Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... | 3 | 18 |
| Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... | 4 | 23 |
| Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... | 3 | 16 |
| Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... | 6 | 19 |
| Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... | 8 | 5 |
| Alpha-1A adrenergic receptor Ligand A-315456 Family | 7 | 17 |
| RAC-gamma serine/threonine-protein kinase and Rho-associated p... | 16 | 46 |
| Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... | 7 | 11 |
| Delta-type opioid receptor and Kappa-type opioid receptor Liga... | 5 | 45 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... | 41 | 59 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... | 8 | 11 |
| Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... | 5 | 13 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... | 219 | 124 |
| Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... | 2 | 29 |
| Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... | 2 | 15 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 24 | 79 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 9 | 16 |
| Type-2 angiotensin II receptor Ligand L-158809 Family | 22 | 136 |
| Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... | 2 | 10 |
| Sodium channel protein type 1 subunit alpha and Sodium channel... | 10 | 14 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 3 | 63 |
| Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... | 6 | 3 |
| RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... | 20 | 90 |
| Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... | 3 | 13 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 14 | 4 |
| Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family | 6 | 13 |
| Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... | 8 | 7 |
| Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... | 4 | 7 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 4 | 2 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 10 | 3 |
| Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... | 3 | 12 |
| Aurora kinase B inhibitor AGN-PC-07ZZ0Y family | 2 | 12 |
| cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... | 13 | 4 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... | 34 | 11 |
| Ephrin type-B receptor 4 ligand SureCN3289519 family | 4 | 2 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 13 | 10 |
| Platelet-activating factor receptor ligand SureCN9384429 family | 11 | 3 |
| Platelet-activating factor receptor ligand AGN-PC-0750SP family | 4 | 0 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 6 | 1 |
| Transient receptor potential cation channel subfamily V member... | 1 | 0 |
| Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... | 4 | 12 |
| Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... | 8 | 7 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 4 | 27 |
| DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... | 2 | 10 |
| Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... | 2 | 7 |
| Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M770 fa... | 2 | 0 |
| Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... | 3 | 11 |
| Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... | 24 | 0 |
| Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... | 8 | 1 |
| Serine/threonine-protein kinase B-raf inhibitor SureCN1013857 ... | 9 | 3 |
| Type-1 angiotensin II receptor and Type-2 angiotensin II recep... | 6 | 27 |
| Type-1B angiotensin II receptor ligand SureCN683399 family | 3 | 0 |
| Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... | 7 | 9 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 4 | 0 |
| Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... | 1 | 8 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... | 7 | 1 |
| Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... | 1 | 2 |
| Prelamin-A/C inhibitor CHEMBL1472945 family | 1 | 32 |
| Survival motor neuron protein and Nuclear receptor ROR-gamma l... | 1 | 2 |
| Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... | 1 | 1 |
| Mitogen-activated protein kinase 13 and Mitogen-activated prot... | 5 | 0 |
| Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... | 3 | 7 |
| Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family | 3 | 1 |
| Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family | 8 | 15 |
| Glycogen synthase kinase-3 beta and Dual specificity protein k... | 4 | 5 |
| Mitogen-activated protein kinase 10 and Transcription factor A... | 4 | 4 |
| Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... | 4 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 5 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 9 | 3 |
| Nociceptin receptor and Potassium voltage-gated channel subfam... | 10 | 1 |
| Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... | 2 | 2 |
| Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... | 4 | 14 |
| Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... | 12 | 2 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 11 |
| Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... | 7 | 4 |
| TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... | 21 | 0 |
| Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 2 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 2 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 2 | 3 |
| Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... | 21 | 6 |
| Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family | 2 | 5 |
| Somatostatin receptor type 5 and Somatostatin receptor type 2 ... | 6 | 3 |
| Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... | 2 | 1 |
| Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... | 9 | 3 |
| Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... | 9 | 2 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 0 |
| Tyrosine-protein kinase JAK2 and ALK tyrosine kinase receptor ... | 5 | 0 |
| Tyrosine-protein kinase JAK2 inhibitor N-[2-[2-[3-chloro-4-(4-... | 2 | 0 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family | 10 | 11 |
| Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... | 11 | 3 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 4 | 2 |
| Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... | 1 | 0 |
| Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... | 2 | 13 |
| Protein kinase C theta type and Leucine-rich repeat serine/thr... | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 11 | 0 |
| Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... | 5 | 3 |
| TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... | 2 | 2 |
| Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... | 3 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 7 | 15 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 14 | 1 |
| Casein kinase II subunit alpha and Homeodomain-interacting pro... | 5 | 0 |
| Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... | 3 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 2 | 1 |
| Fibroblast growth factor receptor 1 and Vascular endothelial g... | 5 | 0 |
| Mitogen-activated protein kinase 14 inhibitor imidazole 81 family | 2 | 1 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family | 8 | 0 |
| High affinity nerve growth factor receptor ligand N-[3-amino-5... | 4 | 10 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family | 16 | 1 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 6 | 2 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 3 | 1 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 2 | 1 |
| Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... | 17 | 0 |
| Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... | 1 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 5 | 6 |
| Somatostatin receptor type 3 and Potassium voltage-gated chann... | 3 | 3 |
| Somatostatin receptor type 3 and Somatostatin receptor type 4 ... | 5 | 1 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family | 2 | 0 |
| Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... | 2 | 0 |
| Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... | 7 | 2 |
| Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... | 2 | 0 |
| Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... | 3 | 0 |
| Protein kinase C theta type and Protein kinase C delta type in... | 2 | 1 |
| Protein kinase C theta type and Protein kinase C delta type in... | 9 | 0 |
| CGMP-dependent protein kinase inhibitor SureCN14561191 family | 4 | 0 |
| Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... | 5 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 1 | 0 |
| Motilin receptor ligand SureCN2004322 family | 2 | 1 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 6 | 0 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... | 2 | 0 |
| Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... | 16 | 0 |
| TGF-beta receptor type-2 and Vascular endothelial growth facto... | 2 | 1 |
| Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... | 9 | 0 |
| ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... | 2 | 0 |
| D(3) dopamine receptor and Muscarinic acetylcholine receptor M... | 8 | 2 |
| Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... | 16 | 0 |
| Cathepsin K inhibitor SureCN4141224 family | 3 | 0 |
| Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... | 5 | 13 |
| Cyclin-dependent kinase 1 inhibitor N-[[5-[(3Z)-3-[4-(methoxym... | 3 | 7 |
| Cathepsin K and Cathepsin S inhibitor SureCN4138353 family | 3 | 0 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 16 | 7 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 3 | 0 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... | 3 | 0 |
| LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... | 4 | 0 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 10 | 0 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 1 | 0 |
| Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... | 1 | 0 |
| Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... | 3 | 0 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 3 | 1 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... | 4 | 0 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 5 | 1 |
| Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... | 2 | 0 |
| High affinity nerve growth factor receptor ligand SureCN490352... | 3 | 0 |
| Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... | 4 | 0 |
| Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... | 3 | 3 |
| Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... | 2 | 1 |
| Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... | 11 | 1 |
| Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... | 4 | 0 |
| Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... | 1 | 0 |
| 5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family | 3 | 1 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 12 | 0 |
| Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family | 7 | 0 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 2 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
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C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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