CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17714
Family Name Macrophage colony-stimulating factor 1 receptor ligand 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carboxamide family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00444053 Functional Category Bioactive
Superfamily Huntingtin and Prelamin-A/C Binder Superfamily 37
Class Class 3457

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Sodium-dependent noradrenaline transporter Inhibitor Neri Iv F... 6 58
Tivozanib family 4 6
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS94Q ... 6 0
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 1 0
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444054 CHEMBL481230 Bioactive 4-(3-chloro-4-fluoroanilino)-7-[2-[2-hydroxyethyl(methyl)amino]ethoxy]-6-methoxyquinoline-3-carboxamide
CFAMM00444053 CHEMBL481231 Bioactive 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carboxamide
CFAMM00444051 CHEMBL481402 Bioactive 4-(3-chloro-4-fluoroanilino)-7-methoxy-6-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carboxamide
CFAMM00444056 CHEMBL480630 Bioactive 4-(3,4-dichloroanilino)-6,7-dimethoxyquinoline-3-carboxamide
CFAMM00444055 CHEMBL519779 Bioactive SureCN5929865

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26412 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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