CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17720
Family Name Transient receptor potential cation channel subfamily V member 1 ligand (1S)-3-oxo-1-phenyl-2-pyridin-2-yl-N-[4-(trifluoromethyl)phenyl]-2,7-diazaspiro[3.5]nonane-7-carboxamide family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00444080 Functional Category Bioactive
Superfamily Mast/stem cell growth factor receptor Kit and Vascular endothelial growth factor receptor 2 Ligand Motesanib Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Amg 423 family 7 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 2 26
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Neuromedin-K receptor and Substance-P receptor ligand AGN-PC-0... 18 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 1 8
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 1
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 9 0
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
Substance-P receptor ligand Netupitant family 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Transient receptor potential cation channel subfamily V member... 57 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 7 6
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Transient receptor potential cation channel subfamily V member... 3 2
Stromelysin-1 and Interstitial collagenase inhibitor 1-[(2S)-1... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444080 CHEMBL481025 Bioactive (1S)-3-oxo-1-phenyl-2-pyridin-2-yl-N-[4-(trifluoromethyl)phenyl]-2,7-diazaspiro[3.5]nonane-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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