CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17725
Family Name Growth hormone secretagogue receptor type 1 ligand [(3S)-3-aminopyrrolidin-1-yl]-[(2S)-1-(4-phenylphenyl)sulfonylpiperidin-2-yl]methanone family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00444092 Functional Category Bioactive
Superfamily Coagulation factor X and Growth hormone secretagogue receptor type 1 Binder Superfamily
Class Class 4312

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Cathepsin K Inhibitor Odanacatib Family 33 84
C-C chemokine receptor type 5 Ligand AZD5672 Family 25 70
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Suppressor of tumorigenicity 14 protein and Prothrombin Inhibi... 4 126
Thymidylate synthase Inhibitor N-[tosyl-d-prolinyl]amino-ethan... 1 10
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Suppressor of tumorigenicity 14 protein Inhibitor 3-tapap Family 15 39
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Trypsin Inhibitor Benzamidrazone Analogue Family 16 6
5-hydroxytryptamine receptor 6 ligand N-[[(1R)-6-(3-fluorophen... 8 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
Calpain-1 catalytic subunit inhibitor 6-chloro-2-methyl-1,1-di... 3 9
Prothrombin inhibitor SureCN7341151 family 6 7
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Disintegrin and metalloproteinase domain-containing protein 17... 6 5
Collagenase 3 and Stromelysin-1 inhibitor (2R,4S)-N-hydroxy-4-... 2 4
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 6 8
Coagulation factor X inhibitor (6S,8aS)-N-[(1-carbamimidoylpip... 6 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor AGN-P... 5 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[2-[... 10 5
Kappa-type opioid receptor and Delta-type opioid receptor liga... 9 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
Bifunctional epoxide hydrolase 2 inhibitor N-cycloheptyl-1-(2,... 7 8
B1 bradykinin receptor ligand N-[(4S)-1-ethyl-3,3-dimethylpipe... 10 4
Neutrophil elastase inhibitor SureCN6619034 family 1 8
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-(naphthalen-2... 3 1
Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0
C-C chemokine receptor type 5 ligand N-[1-[(3R)-4-[benzenesulf... 3 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[2-(3-methy... 1 0
Growth hormone secretagogue receptor type 1 ligand [(3R)-3-ami... 2 5
Cannabinoid receptor 1 ligand SureCN13668467 family 6 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor N-... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 4-... 4 5
Calpain-1 catalytic subunit and Cathepsin B inhibitor (4S)-3-(... 1 0
Secreted frizzled-related protein 1 and Proto-oncogene Wnt-3 i... 14 16
Secreted frizzled-related protein 1 and Proto-oncogene Wnt-3 i... 4 0
Secreted frizzled-related protein 1 and Proto-oncogene Wnt-3 i... 2 5
Secreted frizzled-related protein 1 inhibitor AGN-PC-07R8XQ fa... 3 3
Calpain-1 catalytic subunit and Cathepsin B inhibitor [(3R,5S)... 1 0
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444092 CHEMBL481408 Bioactive [(3S)-3-aminopyrrolidin-1-yl]-[(2S)-1-(4-phenylphenyl)sulfonylpiperidin-2-yl]methanone
CFAMM00444091 CHEMBL517543 Bioactive [(3R)-3-aminopyrrolidin-1-yl]-[(2S)-1-[4-(2,5-difluorophenyl)phenyl]sulfonylpiperidin-2-yl]methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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