CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17766
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D ligand 6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one family
No. of Seeds 18 No. of Other Members 0
Family Centroid CFAMM00250934 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D Binder Superfamily 2
Class Class 2246

Cousin Family NamesSeedsMembers
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Melanin-concentrating hormone receptor 1 Ligand ADS-102891 Family 6 51
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Renin and Cytochrome P450 3A4 inhibitor AGN-PC-046RG9 family 8 28
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 18 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444310 CHEMBL496317 Bioactive 7-fluoro-6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one
CFAMM00444309 CHEMBL489394 Bioactive 8-fluoro-6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one
CFAMM00444308 CHEMBL496520 Bioactive 5-fluoro-6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one
CFAMM00444314 CHEMBL521873 Bioactive 6-[2-[(2R)-2-methyl-4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one
CFAMM00444307 CHEMBL485491 Bioactive 6-[2-[4-(7-fluoro-2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one
CFAMM00444313 CHEMBL497980 Bioactive 6-[2-[4-(8-chloro-2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one
CFAMM00444306 CHEMBL521506 Bioactive 6-[2-[4-(7-chloro-2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one
CFAMM00444312 CHEMBL495705 Bioactive 6-[2-[3-methyl-4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one
CFAMM00444311 CHEMBL495703 Bioactive 6-[2-[(2S)-2-methyl-4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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