CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17767
Family Name Rho-associated protein kinase 1 and Ribosomal protein S6 kinase alpha-1 inhibitor Dihydropyrimidine, 25 family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00444316 Functional Category Bioactive
Superfamily Rho-associated protein kinase 1 and Cytochrome P450 2D6 Binder Superfamily
Class Class 1532

Cousin Family NamesSeedsMembers
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(1h... 2 12
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
cAMP-dependent protein kinase catalytic subunit PRKX and cGMP-... 1 3
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 5
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Rho-associated protein kinase 2 inhibitor 2-[(1S)-1-amino-2-(4... 6 10
Rho-associated protein kinase 2 inhibitor 2-[(3S,4R)-4-(4-fluo... 9 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Rho-associated protein kinase 1 and Cytochrome P450 2D6 inhibi... 4 4
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444320 CHEMBL483401 Bioactive Dihydropyrimidine, 22
CFAMM00444317 CHEMBL485440 Bioactive Dihydropyrimidine, 29
CFAMM00444316 CHEMBL521347 Bioactive Dihydropyrimidine, 25
CFAMM00444315 CHEMBL483395 Bioactive Dihydropyrimidine, 12

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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