CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17791
Family Name Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine deriv. 2d family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00444391 Functional Category Bioactive
Superfamily Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta Binder Superfamily 2
Class Class 712

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
Reverse transcriptase Inhibitor Benzothiadiazines Family 4 21
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BIUF2 family 25 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M82N fa... 13 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... 2 7
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M770 fa... 2 0
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
5-hydroxytryptamine receptor 6 ligand 3-(benzenesulfonyl)-N,5-... 4 1
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 2 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 1
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 15
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Motilin receptor ligand SureCN2004322 family 2 1
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Muscarinic acetylcholine receptor M1 and Cytochrome P450 2C9 l... 2 5
Glucocorticoid receptor ligand N-ethyl-4-fluoro-N-[3,3,3-trifl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444391 CHEMBL484571 Bioactive Imidazo[1,2-b]pyridazine deriv. 2d
CFAMM00444389 CHEMBL520003 Bioactive Imidazo[1,2-b]pyridazine deriv. 2b

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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