CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17796
Family Name Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylphenoxy)phenyl]-1-oxo-2-propyl-3,4-dihydroisoquinoline-4-carboxylic acid family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00444403 Functional Category Bioactive with Natural Product
Superfamily Integrin beta-3 and Integrin alpha-IIb Binder Superfamily 21
Class Class 216

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
P2X purinoceptor 3 Inhibitor A-317491 Family 1 2
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 5 11
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-7-[(4-ca... 3 14
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[2,6-dimethyl-4-[3-... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
Estrogen receptor and Estrogen receptor beta ligand SureCN1450... 1 1
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-074LOQ... 3 0
Metabotropic glutamate receptor 2 ligand SureCN787402 family 1 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444402 CHEMBL485006 Bioactive (3R,4R)-3-[4-(3,5-dimethylphenoxy)phenyl]-1-oxo-2-propyl-3,4-dihydroisoquinoline-4-carboxylic acid
CFAMM00444406 CHEMBL519525 Bioactive (3R,4R)-2-(cyclopropylmethyl)-1-oxo-3-(4-phenoxyphenyl)-3,4-dihydroisoquinoline-4-carboxylic acid
CFAMM00444405 CHEMBL484771 Bioactive (3R,4R)-3-[4-(4-methylcyclohexyl)oxyphenyl]-1-oxo-2-propyl-3,4-dihydroisoquinoline-4-carboxylic acid
CFAMM00444403 CHEMBL485007 Bioactive (3R,4R)-3-[4-(3,4-dimethylphenoxy)phenyl]-1-oxo-2-propyl-3,4-dihydroisoquinoline-4-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27257 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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