CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM178
Family Name Protein farnesyltransferase subunit beta and Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha inhibitor 2-[[2-[(3S)-3-[[(2S)-2-amino-3-sulfanylpropanoyl]-methylamino]-2-oxo-5-phenyl-4,5-dihydro-3H-1,4-benzodiazepin-1-yl]acetyl]amino]-4-methylsulfanylbutanoic acid family
No. of Seeds 3 No. of Other Members 5
Family Centroid CFAMM00308411 Functional Category Bioactive
Superfamily Neprilysin and Angiotensin-converting enzyme Binder Superfamily
Class Class 3095

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Neprilysin Inhibitor Thiorphan Family 41 68
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Dipeptidyl peptidase 4 inhibitor SureCN1499864 family 4 7
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
fMet-Leu-Phe receptor ligand (2S)-2-[[(2S)-2-[[(2S)-2-[(4-chlo... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 4 4
Angiotensin-converting enzyme inhibitor 89177-63-9 family 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00308411 CHEMBL103799 Bioactive 2-[[2-[(3S)-3-[[(2S)-2-amino-3-sulfanylpropanoyl]-methylamino]-2-oxo-5-phenyl-4,5-dihydro-3H-1,4-benzodiazepin-1-yl]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00308404 CHEMBL319904 Bioactive methyl 2-[[2-[(3S)-3-[[(2S)-2-amino-3-sulfanylpropanoyl]-methylamino]-2-oxo-5-phenyl-4,5-dihydro-3H-1,4-benzodiazepin-1-yl]acetyl]amino]-4-methylsulfanylbutanoate
CFAMM00308407 CHEMBL418572 Bioactive (2S)-2-[[2-[(3S)-3-[[(2R)-2-amino-3-sulfanylpropanoyl]-methylamino]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]acetyl]amino]-4-methylsulfanylbutanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27160 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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